题目

英语翻译
CDR-H3 resides in the center of the P5a/P5c helical interface at
the three-helix junction (Fig.5A).Residues Gly-98,Ser-100,and
Thr100a interact with the wide and shallowminor groove of P5c via
direct H bonds,and Tyr-102 contacts P5a by H bonding to U131 in
the minor groove.Several CDR-H3 residues form a pocket (Fig.
5B) that encloses U130,the bulged uridine in P5a,and they use a
variety of molecular strategies to interact with U130.Arg-94,
Ala-96,Asp-101,and Gly100c form direct H bonds to the uracil
base and sugar ring,whereas the side chains of Ala-96 and Met-99
embrace the nucleotide with nonpolar contacts.Tyr100b stacks
perpendicularly with the base,and Arg-94 forms an N-O bridgetype
of ion pair with the adjacent phosphate (36).Interestingly,
although Arg-95 was selected from the library,it makes no interaction
with the RNA in the structure; instead,its side chain points
away from theRNAand makes hydrogen bonding inter

提问时间：2021-04-01

答案

CDR-H3居住在中心的P5a / P5c螺旋接口three-helix交界处的(图5).残留Gly - 98,萨尔- 100,Thr100a交互槽宽,shallowminor P5c通过直接H债券,和接触P5a钟- 102通过催眠与U131小槽.几个CDR-H3残留(图形成一个口袋里.5 B)...